微生物与生化药学方向

解云英

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时间:2021-07-07    

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解云英   微生物化学室   研究员   硕士生导师

教育背景及研究工作经历:先后就读于山东大学药学院(1998-2002学士)和北京协和医学院(2002-2007博士);2007年起于中国医学科学院&北京协和医学院医药生物技术研究所从事科研教学工作,2017年赴澳大利亚昆士兰大学进行代谢组学方向的访学研究。

主要研究方向:抗感染、抗肿瘤及降脂微生物药物的发现

专业研究领域:近年来一直致力于抗感染、抗肿瘤及降脂等微生物药物的发现。在传统活性导向先导化合物发现的基础上,将近年来发展起来的基因组测序技术、生物信息学、合成生物学与代谢组学技术结合起来,建立了更高效的药物先导化合物发现平台。

代表性论文:

1. Li Y, He N, Luo M, Hong B*, Xie Y*. Application of Untargeted Tandem Mass Spectrometry with Molecular Networking for Detection of Enniatins and Beauvericins from Complex Samples. Journal of Chromatography A 2020: 461626

2. Li,Y.; Liu, L.; Zhang, G.; He, N.; Guo, W.; Hong, B.; Xie, Y.*,Potashchelins, a Suite of Lipid Siderophores Bearing Both L-threo and L-erythroBeta-Hydroxyaspartic Acids, Acquired From the Potash-Salt-Ore-Derived ExtremophileHalomonas sp. MG34. Frontiers inChemistry 2020, 8.

3. Shi, Y.; Gu, R.; Li, Y.; Wang,X.; Ren, W.; Li, X.; Wang, L.; Xie, Y. *; Hong, B. *, Exploring novelherbicidin analogues by transcriptional regulator overexpression and MS/MSmolecular networking. Microb Cell Fact 2019, 18, 175.

4. Shi, Y.; Wang, X.; He, N.; Xie,Y. *; Hong, B. *, Rescrutiny of the sansanmycin biosynthetic gene cluster leads tothe discovery of a novel sansanmycin analogue with more potency againstMycobacterium tuberculosis. J Antibiot(Tokyo) 2019, 72, 769-774.

5. Qi, X.; Li, X.; Zhao, J.; He,N.; Li, Y.; Zhang, T.; Wang, S.; Yu, L. *; Xie, Y. *, GKK1032C, a newalkaloid compound from the endophytic fungus Penicillium sp. CPCC 400817 withactivity against methicillin-resistant S. aureus. J Antibiot (Tokyo) 2019,72, 237-240.

6. Jiang, Z. B.; Ren, W. C.; Shi,Y. Y.; Li, X. X.; Lei, X.; Fan, J. H.; Zhang, C.; Gu, R. J.; Wang, L. F.; Xie,Y. Y.*; Hong, B.*, Structure-based manual screening and automaticnetworking for systematically exploring sansanmycin analogues using highperformance liquid chromatography tandem mass spectroscopy. J Pharm BiomedAnal 2018, 158, 94-105.

7. Qi,X.; Wang, X.; Ren, H.; Zhang, F.; Zhang, X.; He, N.; Guo, W.; Chen, R.; Xie, Y.*; He, Q.*, NC1404, a novelderivative of Bleomycin with modified sugar moiety obtained during thepreparation of Boningmycin. J Antibiot(Tokyo) 2017, 70, 970-973.

8. Wang, S.; Zhang, N.; He, N.; Guo, W.; Lei, X.; Cai, Q.; Hong,B.; Xie, Y. *, Exploiting SubstrateDiversity of NRPS led to the generation of new sansanmycin analogs. Nat Prod Commun 2017,12(5),781-783.

9. Zhang, N.;Liu, L.; Shan, G.; Cai, Q.; Lei, X.; Hong, B.; Wu, L.; Xie, Y.*; Chen, R.*, Precursor-directed biosynthesis of newsansanmycin analogs bearing para-substituted-phenylalanines with high yields. J Antibiot (Tokyo) 2016, 69, (10), 765-768.

10. Shi, Y.;Jiang, Z.; Lei, X.; Zhang, N.; Cai, Q.; Li, Q.; Wang, L.; Si, S.; Xie, Y.*; Hong, B.*, Improving theN-terminal diversity of sansanmycin through mutasynthesis. Microb Cell Fact 2016,15, (1), 77.

11. Xie, Y.; Cai, Q.;Ren, H.; Wang, L.; Xu, H.; Hong, B.; Wu, L.; Chen, R., NRPS substratepromiscuity leads to more potent antitubercular sansanmycin analogues. J Nat Prod 2014, 77, (7), 1744-8.

12. Li, Q.; Wang,L.; Xie, Y.; Wang, S.; Chen, R.;Hong, B., SsaA, a member of a novel class of ranscriptional regulators,controls sansanmycin production in Streptomyces sp. strain SS through afeedback mechanism. J Bacteriol 2013, 195, (10), 2232-43.

13. Tang, X.;Gross, M.; Xie, Y.; Kulik, A.; Gust,B., Identification of mureidomycin analogues and functional analysis of anN-acetyltransferase in napsamycin biosynthesis. Chembiochem 2013, 14,(17), 2248-55.

14. Wang, L.; Xie, Y. co-first author; Li, Q.; He, N.; Yao, E.; Xu, H.; Yu, Y.; Chen, R.; Hong,B., Draft genome sequence of Streptomyces sp. strain SS, which produces aseries of uridyl peptide antibiotic sansanmycins. Journal of bacteriology 2012,194, (24), 6988-9.

15. Li, Y. B.; Xie, Y. Y. (co-first author); Du, N.N.; Lu, Y.; Xu, H. Z.; Wang, B.; Yu, Y.; Liu, Y. X.; Song, D. Q.; Chen, R. X.,Synthesis and in vitro antitubercular evaluation of novel sansanmycinderivatives. Bioorganic & medicinalchemistry letters 2011, 21,(22), 6804-7.

专利:

1. 解云英,陈汝贤,许鸿章,洪斌,何宁,侍媛媛,前体定向生物合成的尿苷肽类抗生素及其用途,ZL 201611142063.6,已授权,授权公告日:20191017

2. 解云英, 陈汝贤,许鸿章, 俞莹, 姚恩泰, 何宁, 任浩, 蔡强, 新颖的尿苷肽类抗生素及其用途,中国专利,专利号:ZL 201110450030.9,已授权,授权公告日:2014910

3. 洪斌,解云英,侍媛媛,江志波,雷璇,张宁宁,蔡强,李青连,王丽非,司书毅,利用突变合成获得SANSANMYCIN结构类似物的方法,中国专利,专利号:ZL 201610219358.2,已授权,授权公告日:20200211

4. 许鸿章,陈汝贤,解云英,一组尿苷肽类抗生素和其药学上可接受的盐、及其制备方法和用途,中国专利,专利号:ZL 200610141075.7,已授权,授权公告日:20121024

5. 许鸿章,许鸿源,解云英,陈汝贤,梁琼月. 一种生产半夏胚状体和组培苗的方法,中国专利,专利号:ZL 201010113222,已授权,授权公告日:20121024

6. 陈汝贤,许鸿章,鲁敏,任浩,解云英,新型博来霉素类似物及其制备方法和用途,中国专利,专利号:ZL 201110302895.0,已授权,授权公告日:2014115

7. 陈汝贤,宋丹青,李阳彪,解云英,许鸿章,俞莹,新的尿苷肽类抗生素及其作为抗结核病药物的用途,中国专利,专利号:ZL 201210172768.8,已授权,授权公告日:201501 28

8. 陈汝贤,任浩,张峰,解云英,何琪杨,许鸿章,鲁敏,博来霉素衍生物和用途,中国专利,申请号:201510033184.6,申请日期:20150122

9. 陈汝贤,许鸿章,陈彩霞,鲁敏,石莲英,解云英,一种抗肿瘤抗生素和其药学上可接受的盐、及其制备方法和用途,中国专利,专利号:ZL 200810116643.7,已授权,授权公告日:20111116

学术任职:《中国抗生素杂志》青年编委,国家化妆品抽检专家,教育部学位与研究生教育通讯评议专家,《Journal of Medicinal Chemistry》、《Journal of Natural Products》、《Journal of Chromatography A》等杂志的评审专家。

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电子邮箱:xieyy@imb.pumc.edu.cn

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