微生物与生化药学方向

张德武

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时间:2021-07-07    

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张德武   菌种保藏室   副研究员   硕士生导师

教育背景及工作经历:

2016/07-至今 世界杯在哪里买球 副研究员

2013/09-2016/07 世界杯在哪里买球 助理研究员

2010/09-2013/07 北京协和医学院药物研究所 理学博士

2007/09-2010/07 烟台大学药学院 医学硕士

2003/09–2007/07 烟台大学药学院 医学学士

主要研究方向:微生物天然产物化学及其合成生物学研究

专业研究领域:微生物活性次级代谢产物的发现与合成生物学研究。主要包括:1、紧密结合高通量筛选、基因组挖掘技术以及现代分析技术从特殊生境(植物内生、地衣、沙漠、高原、南北极、海洋等)来源的微生物中快速发现新颖结构的活性天然产物。2、对发现的新颖活性天然产物利用合成生物学技术进行结构改造,并对重要天然产物进行生物合成途径解析。近年主持了国家自然科学基金-面上项目、国家自然科学基金-青年项目各一项,以科研骨干参与了国家自然科学基金-中美(NSFC-NIH)国际合作项目、国家“863”计划、重大新药创制、国家科技基础条件平台、中国医学科学院医学与健康科技创新工程等多项课题的研究。在国内外学术期刊发表研究论文50篇,其中SCI论文30余篇,以第一作者/通迅作者在Organic LettersJournal of Natural Products等国内外重要期刊发表学术论文27篇。有3个化合物被国际权威期刊Nat. Prod. Rep.选为全球热点化合物。有10余个化合物在发表后迅速的被国内外同行进行了全合成研究。参与申请专利5项。

代表性论文:

1. Su Cong, Tao Xiaoyu, Yin Zhen, Zhang Xiaolin, Tian Jinying, Chen Ridao, Liu Jimei, Li Li, Ye Fei, Zhang Peicheng, Zhang Dewu*, Dai Jujgui*. Morusalones A-D, Diels-Alder adducts with 6/7/6/6/6/6 hexacyclic ring systems as potential PTP1B inhibitors from cell culutres of Morus alba. Org. Lett. 2019, 21: 9463-9467.

2. Fan Yijun#, Zhang Dewu#, Tao Xiaoyu, Wang Yuanhao, Liu Jimei, Li Li, Zhao Jianyuan, Yu Liyan, He Yupeng, Dai Jungui*, Tang Yefeng*. Biosynthetic hypothesis-guided discovery and total syntheses of PKS-NRPS hybrid metabolites from endophytic fungus Periconia species. Org. Lett. 2019, 21: 1794-1798. (# co-first author)

3. Zhang Dewu, Tao Xiaoyu, Chen Ridao, Liu Jimei, Li Li, Fang Xiaomei, Yu Liyan, Dai Jungui *. Pericoannosin A, a polyketide synthase-nonribosomal peptide synthetase hybrid metabolite with new carbon skeleton from the endophytic fungus Periconia sp. Org. Lett. 2015, 17: 4304-4307.

4. Zhang Dewu, Ge Hanlin, Zou Jian-Huan, Tao Xiaoyu, Chen Ridao, Dai Jungui*. Periconianone A, a new 6/6/6 carbocyclic sesquiterpenoid from endophytic fungus Periconia sp. with anti-inflammatory activity. Org. Lett. 2014, 16: 1410-1413.

5. Zhang Dewu, Ge Hanlin, Xie Dan, Chen Ridao, Zou Jian-Hua, Tao Xiaoyu, Dai Jungui*. Periconiasins A-C, new cytotoxic cytochalasans with an unprecedented 9/6/5 tricyclic ring system from endophytic fungus Periconia sp. Org. Lett. 2013, 15: 1674-1677.

6. Zhang Dewu, Zhao Lili, Wang Lining, Fang Xiaomei, Zhao Jianyuan, Wang Xinwei, Li Li, Liu Hongyu, Wei Yuzhen, You Xuefu, Cen Shan, Yu Liyan*. Griseofulvin derivative and indole alkaloids from Penicillium griseofulvum CPCC 400528. J. Nat. Prod. 2017, 80: 371-376.

7. Zhang Dewu#, Guo Jiamei#, Zhang Min, Liu Xiao, Ba Mingyu, Tao Xiaoyu, Yu Liyan, Guo Ying*, Dai Jungui*. Oxazole-containing diterpenoids from cell cultures of Salvia miltiorrhiza and their anti-HIV-1 activities. J. Nat. Prod. 2017, 80: 3241-3246. (# co-first author)

8. Zhang Dewu, Tao Xiaoyu, Gu Guowei, Wang Yujia, Zhao Wenxia, Zhao Wuli, Ren Yan*, Dai Shengjun*, Yu Liyan*. Microbial transformation of neo-clerodane diterpenoid, scutebarbatine F, by Streptomyces sp. CPCC 205437. Front. Microbiol. 2021, 12, 62321.

9. Liu Jimei#, Zhang Dewu#, Zhang Min, Zhao Jinlian, Chen Ridao, Wang Nan, Zhang Dan, Dai Jungui*. Eremophilane sesquiterpenes from an endophytic fungus Periconia species. J. Nat. Prod. 2016, 79: 2229-2235. (# co-first author)

10. Guo Guowei, Cai Guowei, Wang Yujia, Li Li, Bai Jinglin, Zhang Tao, Cen Shan, Zhang Dewu*, Yu Liyan*. Daldispones A and B, two new cyclopentenones from Daldinia sp. CPCC 400770. J. Antibiot. 2021, 74, 215-218.

11. Zhang Dewu, Zhao Jianyuan, Wang Xinwei, Zhao Lili, Liu Hongyu, Wei Yuzhen, You Xuefu, Cen Shan, Yu Liyan*. Peniazaphilin A, a new azaphilone derivative produced by Penicillium sp. CPCC 400786. J. Antibiot. 2018, 71: 905-907.

12. Zhang Dewu, Tao Xiaoyu, Liu Jimei, Chen Ridao, Zhang Min, Li Li, Fang Xiaomei, Yu Li-Yan*, Dai Jungui*. Periconiasin G, a new cytochalasan with unprecedented 7/6/5 tricyclic ring system from the endophytic fungus Periconia sp. Tetrahedron Lett. 2016, 57: 796-799.

13. Liu Ji-Mei#, Zhang De-Wu#, Zhang Min, Chen Ri-Dao, Yan Zheng, Zhao Jian-Yuan, Zhao Jin-Lian, Wang Nan, Dai Jun-Gui*. Periconones B-E, new meroterpenoids from endophytic fungus Periconia sp. Chin. Chem. Lett. 2017, 28: 248-252. (# co-first author)

14. Zhang De-Wu, Tao Xiao-Yu, Liu Ji-Mei, Chen Ri-Dao, Zhang Min, Fang Xiao-Mei, Yu Li-Yan*, Dai Jun-Gui*. A new polyketide synthase-nonribosomal peptide synthetase hybrid metabolite from plant endophytic fungus Periconia sp. Chin. Chem. Lett. 2016, 27: 640-642.

15. Liu Ji-Mei#, Zhang De-Wu#, Du Wen-Yu, Zhang Min, Zhao Jin-Lian, Chen Ri-Dao, Xie Ke-Bo, Dai Jun-Gui*. Four new monoterpenoids from an endophytic fungus Periconia sp. F-31. J. Asian Nat. Prod. Res. 2017, 19: 541-549. (# co-first author)

16. Zhang De-Wu#, Tao Xiao-Yu#, Chen Ri-Dao, Yu Li-Yan, Dai Jun-Gui*. Regio-selective deglycosylation of icariin by cell suspension cultures of Glycyrrhiza uralensis and Morus alba. J. Asian Nat. Prod. Res. 2015, 17: 656-661. (# co-first author)

17. Zhang De-Wu#, Tao Xiao-Yu#, Yu Li-Yan, Dai Jun-Gui*. New 2-arylbenxofuran metabolite from cell cultures of Morus alba. J. Asian Nat. Prod. Res. 2015, 17: 683-688. (# co-first author)

18. Zhang De-Wu, Liu Xiao, Xie Dan, Chen Ridao, Tao Xiao-Yu, Zou Jian-Hua, Dai Jungui*. Two new diterpenoids from cell cultures of Salvia miltiorrhiza. Chem. Pharm. Bull. 2013, 61: 576-580.

19. Zhang De-Wu, Yang Yan, Yao Fang, Yu Qun-Ying, Dai Sheng-Jun*. Solalyratins A and B, new anti-inflammatory metabolites from Solanum lyratum. J. Nat. Med. 2012, 66: 362-366.

20. Zhang De-Wu, Li Gui-Hai, Yu Qun-Ying, Dai Sheng-Jun*. New anti-inflammatory 4-hydroxyisoflavans from Solanum lyratum. Chem. Pharm. Bull. 2010, 58: 840-842.

21. Zhang De-Wu, Dai Sheng-Jun, Liu Wan-Hui, Li Gui-Hai*. Chemical constituents from the vines of Pueraria lobata. Chin. J. Nat. Med. 2010, 8 (3): 196-198.

荣誉奖励:曾获山东省科学技术奖、烟台大学科学技术进步二等奖、中国药学大会优秀论文二等奖、北京协和医学院院校优秀博士学位论文提名等多项奖励。

学术任职:中国菌物学会药用真菌专业委员会委员;《中国抗生素杂志》青年编委;《Bioorganic Chemistry》、《Frontiers in Microbiology》、《Current Medicinal Chemistry》、《Open Chemistry》、《中国抗生素杂志》、《天然产物研究与开发》、《生物资源》等杂志审稿专家。

联系电话:010-63017304

电子邮箱:zhangdewu@imb.pumc.edu.cn

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世界杯买球-世界杯在哪里买球「2022年卡塔尔世界杯」