微生物与生化药学方向

王静

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时间:2021-07-07    

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王静   免疫生物学室   副研究员   硕士生导师

教育背景及工作经历:

2019/10-至今  世界杯在哪里买球 副研究员

2013/09-2019/09 世界杯在哪里买球 助理研究员

2008/09-2013/07 北京协和医学院基础医学研究所 生物化学与分子生物学系 硕博连读,

2004/09-2008/07 中央民族大学生命与环境科学学院 本科

主要研究方向:病毒学基础研究和抗病毒药物应用研究

专业研究领域:主要从事病毒与宿主的相互作用研究,及新型抗病毒药物靶点的发现。近年来致力于宿主长链非编码RNAlncRNAs)在流感病毒复制过程中的功能及机制探讨。首次利用loss-of-function策略,筛选获得了一系列功能性lncRNAs,并首次揭示了候选lncRNAs在病毒感染中的新功能及作用机制,以期后续构建完整的流感病毒-lncRNA调控网络,为新抗病毒疗法的发展提供新思路。以第一/通讯作者身份,将该部分成果分别发表于Cell子刊Cell ReportsVirusesEmerging Microbes & Infections等国际学术期刊,并授权专利1项。同时还参与了多个课题研究,在J Virol.BBAR:MCRActa Pharm Sin BSci Rep.Antiviral Res.BMC CancerRetrovirology等专业刊物上发表SCI论文10余篇,国家发明专利2项。先后主持承担协和青年基金及滚动项目、北京市重点实验室、国家自然科学基金青年和面上项目,并参与国家重点研发计划、传染病防治重大专项及中国医学科学院协同创新团队项目等。

代表性论文:

1. Jing Wang#, Yongxin Zhang#, Quanjie Li, Jianyuan Zhao, Dongrong Yi, Jiwei Ding, Fei Zhao, Siqi Hu, Jinming Zhou, Tao Deng, Xiaoyu Li*, Fei Guo, Chen Liang, and Shan Cen*, Influenza virus exploits an interferon-independent lncRNA to preserve viral RNA synthesis through stabilizing viral RNA polymerase PB1. Cell Reports, 2019, 27, 3295–3304.

2. Jing Wang* and Shan Cen*. Roles of lncRNAs in influenza virus infection. Emerg Microbes Infect. 2020, 9 (1):1407-1414.

3. Jing Wang, Yujia Wang, Rui Zhou, Jianyuan Zhao, Yongxin Zhang, Dongrong Yi, Quanjie Li, Jinming Zhou, Fei Guo, Chen Liang, Xiaoyu Li and Shan Cen*, Host long noncoding RNA lncRNA-PAAN regulates the replication of Influenza A Virus. Viruses, 2018, 10, 330.

4. Ling-xia Wang#, Jing Wang#, Ting-ting Qu, Ye Zhang*, Yu-fei Shen*, Reversible acetylation of Lin28 mediated by PCAF and SIRT1. Biochimica et Biophysica Acta: Molecular Cell Research, 2014, 1843(6): 1188-1195.

5. Jianyuan, Saisai Guo, Dongrong Yi, Quanjie Li, Ling Ma, Yongxin Zhang, Jing Wang, Xiaoyu Li, Fei Guo, Rongtuan Lin, Chen Liang, Zhenlong Liu*, Shan Cen*, A cell-based assay to discover inhibitors of SARS-CoV-2 RNA dependent RNA polymerase. Antiviral Research.

6. Dong-Rong Yi#, Ni An#, Zhen-Long Liu, Feng-Wen Xu, Kavita Raniga, Quan-Jie Li, Rui Zhou, Jing Wang, Yong-Xin Zhang, Jin-Ming Zhou, Lei-Liang Zhang, Jing An, Cheng-Feng Qin, Fei Guo, Xiao-Yu Li, Chen Liang, Shan Cen*, Human MxB inhibits the replication of hepatitis C virus. J Virol, 2019, 93:e01285-18.

7. Quanjie Li#, Ling Ma#, Dongrong Yi#, Han Wang, Jing Wang, Yongxin Zhang, Ying Guo, Xiaoyu Li, Jinming Zhou*, Yi Shi*, George F. Gao, Shan Cen*, Novel cyclo-peptides inhibit Ebola pseudotyped virus entry by targeting primed GP protein. Antiviral Res., 2018, 155:1-11.

8. Ling Ma, Zhixin Zhang, Zhenlong Liu, Qinghua Pan, Jing Wang, Xiaoyu Li, Fei Guo, Chen Liang, HuLaixing Hu, Jinming Zhou*, Shan Cen*, Identification of small molecule compounds targeting the interaction of HIV-1 Vif and human APOBEC3G by virtual screening and biological evaluation. Sci Rep., 2018, 8(1):8067.

9. Ting-ting Qu#, Fei Chen#, Jing Wang, Yan-jun Zhang, Mo-bin Cheng, Wen-zheng Sun, Yu-fei Shen and Ye Zhang*, PCAF-mediated acetylation of Lin28B increases let-7 biogenesis in lung adenocarcinoma H1299 cells. BMC Cancer, 2018, 18: 27.

10. Congjie Zhai, Ling Ma, Zhixin Zhang, Jiwei Ding, Jing Wang, Yongxin Zhang, Xiaoyu Li, Fei Guo, Liyan Yu, Jinming Zhou, Shan Cen*, Identification and characterization of loop7 motif and its role in regulating biological function of human APOBEC3G through molecular modeling and biological assay. Acta Pharm Sin B, 2017,7(5):571-582.

11. Quan Zhang#, Zeyun Mi#, Yuming Huang#, Ling Ma, Jiwei Ding, Jing Wang, Yongxin Zhang, Yang chen, Jinming Zhou, Fei Guo, Xiaoyu Li and Shan Cen*, 2-thio-6-azauridine inhibits Vpu mediated BST-2 degradation. Retrovirology, 2016, 13:13.

专利:

1. 岑山、王静、张永欣、衣岽戎、李泉洁。以IPAN或其编码基因为靶点的物质在制备流感病毒抑制剂中的应用,ZL201910276034.6,授权日:2021-03-12

2. 岑山、李泉洁、马铃、衣岽戎、王静、张永欣。与埃博拉病毒激活态包膜糖蛋白特异性结合的多肽及其在抗病毒中的应用,ZL201810087839.1,授权日:2020-06-16 

3. 岑山,李泉洁,马铃,衣岽戎,王静,张永欣,多肽及其在抗埃博拉病毒中的应用,中国发明专利申请:202010460222.7,申请日:2020-05-02

联系电话:010-63131011

电子邮箱:jingwang@imb.pumc.edu.cn

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世界杯买球-世界杯在哪里买球「2022年卡塔尔世界杯」