微生物与生化药学方向

刘秀均

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时间:2021-07-07    

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刘秀均   肿瘤研究室   副研究员   硕士生导师

教育背景及工作经历:

1996年毕业于中国药科大学药理专业获学士学位,2001年毕业于中国协和医科大学获微生物与生化药学硕士学位。1996年自中国药科大学药理专业毕业至今在世界杯在哪里买球肿瘤研究室在甄永苏院士带领下从事抗肿瘤药物研究。

主要研究方向: 肿瘤药理、抗体工程

专业研究领域:1、抗肿瘤抗生素2、抗肿瘤靶向药物3、新型生化调节剂以及多功能抗肿瘤组合药物研究4、抗肿瘤纳米药物5、细胞因子风暴综合症及治疗药物

代表性论文:

1. Shiming He, Jian Xu, Xiujun Liu, Yongsu Zhen. Advances and challenges in the treatment of esophageal cancer.Acta Pharmaceutica Sinica B,2021,

https://doi.org/10.1016/j.apsb.2021.03.008

2.Mengran Zhang, Hao Cai, Yue Du, Yuexuan Wang, Jianhua Gong, Jian Xu, and Xiujun Liu. Enhancing the Therapeutic Efficacy of Gefitinib in Human Non-Small-Cell Lung Cancer through Drug Combination. Molecular Pharmaceutics, 2021 Jan 20. doi: 10.1021/acs.molpharmaceut.0c01203.

3. ChuanKun Shan, YiBo Du, XiaoTian Zhai, YueXuan Wang, Yi Li, JianHua Gong. Zhi Juan Ge,.XiuJun Liu, YongSu Zhen. Pingyangmycin enhances the antitumor efficacy of anti-PD-1 therapy associated with tumor infiltrating CD8+ T cell augmentation. Cancer Chemotherapy and Pharmacology, 2021 Jan 3. DOI: 10.1007/s00280-020-04209-7. Online ahead of print.

4. Yan-Bo Zheng, Meng-Ran Zhang, Yi Li, Xiu-Jun Liu, and Yong-Su Zhen. DBDx-based drug combinations show highly potent therapeutic efficacy against human pancreatic cancer xenografts in athymic mice. Cancer Biology & Therapy 2020 Aug 2;21(8):749-757.doi: 10.1080/15384047.2020.1776580. Epub 2020 Jun 17.

5.Jian-Hua Gong, Yan-Bo Zheng, Meng-Ran Zhang, Yue-Xuan Wang, Si-Qi Yang, Rui-Hai Wang, Qing-Fang Miao, Xiu-Jun Liu & Yong-Su Zhen.“Dexamethasone enhances the antitumor efficacy of Gemcitabine by Glucocorticoid receptor signaling” Cancer Biology & TherapyDOI: 10.1080/15384047.2019.1702399. https://doi.org/10.1080/ 15384047.2019.1702399

6.Xu J, Du Y, Liu WJ, Li L, Li Y, Wang XF, Yi HF, Shan CK, Xia GM, Liu XJ, Zhen YS. Intensive fibrosarcoma-binding capability of the reconstituted analog and its antitumor activity. Drug Deliv., 2018, 25(1), 102-111

7.Wuli Zhao, Caixia Zhang, Chongwen Bi, Cheng Ye, Danqing Song, Xiujun Liu and Rongguang Shao.Sophoridinol derivative 05D induces tumor cells apoptosis by topoisomerase1-mediated DNA breakage. Oncotargets and Therapy. 20169):2805-2817

8. Chunlan Wang, Guimin Xia, Yun Chai, Xiujun Liu, * Rui Zhang, Jun Zhang, Xiaoning Li, Yang Yang, Juxian Wang, Mingliang Liu.* Synthesis and antitumor activity of ATB-429 derivatives containing a nitric oxide-releasing moiety. Bioorg Med Chem Lett. Doi:10.1016/ j.bmcl.2016.03.012

9.JIA Xuedong,LIU Xiujun, WANG Jian, WANG Minghua,GUO Huiyuan and LIU Mingliang.

Synthesis and Antitumor Activity of Capecitabine Derivatives. Chem. Res. Chin. Univ., 2015, 31(1):78-83.

10. Liu XJ, Zheng YB#, Li Y, Wu SY, Zhen YS.A Multifunctional Drug Combination Shows Highly Potent Therapeutic Efficacy against Human Cancer Xenografts in Athymic Mice.PLoS One. 2014, 22;9(12):e115790.

专利:

1.硝基苯甲酸类化合物在制备治疗肿瘤的药物中的应.专利号:ZL202010203050.5 授权日2021.03.26

2.一种基于抗体和巨胞饮的双靶向抗肿瘤重组蛋白的制备及用途.专利号:ZL201711390128.3 授权日:2020.8.7

3.一种抗肿瘤融合蛋白EL-defensin、其编码基因和用途.专利号:ZL 201310566425.4 授权日 : 2020.04.10

4.一类防御素-白蛋白的抗肿瘤融合蛋白及其制备和应用.专利号:ZL 201510674664.0 授权日 : 2019.10.01

5.一种哒嗪酮类化合物在肿瘤治疗中的应用.专利号:ZL 201710429186.6 授权日:2019.03.05

6.一类基于基质金属蛋白酶组织抑制剂‑2的抗肿瘤药物制备及用途.专利号ZL201510189147.4 授权日 : 2017.11.28

7.IMB5046化合物在制备抗肿瘤药物中的用途。专利号 :ZL201510397191.4 授权日 : 2017.04.26

8.抗肿瘤抗生素安可霉素及其衍生物。专利号: ZL201110124932.3 授权日: 2014.12.31

9.具有抗肿瘤作用的药物组合物及其应用。专利号: CN201010133844.5授权日: 2013.08.21

10.双活性成分抗肿瘤药物及其应用。专利号:ZL201010133858.7 授权日: 2013.11.06

联系电话:01063010985

电子邮箱:Liuxiujun2000@imb.pumc.edu.cn

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世界杯买球-世界杯在哪里买球「2022年卡塔尔世界杯」

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